Atualidades em Síndrome de Sjögren

Este ano programei nova ida ao encontro da AAOM em San Antonio, no Texas. Farei a apresentação de um poster sobre o 1º Polo de DTM e Dor Orofacial na rede municipal de saúde do Rio de Janeiro, onde atendemos eu e a Dra. Laira Soares.

Dentre as atividades do encontro selecionei uma que valerá a pena assistir.

__________________________________

Another highlight of this year’s Annual Meeting will be the Sjögren’s Syndrome Update on Thursday, April 25, presented by Dr. Troy Daniels, of the University of California – San Francisco.

Sjögren’s syndrome (SS) was assigned its first diagnostic criteria in 1965, followed by 11 more in subsequent years, several of which continue to be used to identify patients for individual treatment, clinical trials or research studies. Given recent advances in knowledge of autoimmune diseases and new systemic treatment being developed for their treatment, classification criteria to select participants for clinical trials or other research studies on SS must now focus on its autoimmune nature and be as disease-specific as possible.

Between 2003 and 2013 a large international SS cohort registry was funded by the NIH including nine collaborating sites in seven countries and called the Sjögren’s International Collaborative Clinical Alliance (SICCA). The SICCA project protocols supported:

1) uniform multidisciplinary evaluation and specimen collection from each of 3,500 participants;
2) creation of an extensive data and specimen bank to support future research; and
3) development of a new, simplified and focused classification criteria for SS, recently approved and adopted by the American College of Rheumatology.

Dr. Daniels’ presentation will outline development of the new SS classification criteria based on association analyses of oral and ocular symptoms, salivary flow rates, salivary gland biopsy diagnoses, serology and ocular testing, against the phenotypic features of SS. Genome wide association analyses of DNA from the SICCA data bank, giving us new insight into the autoimmune nature of SS and its components, will also be presented.

__________________________

2 respostas para “Atualidades em Síndrome de Sjögren”

Deixe uma resposta

O seu endereço de e-mail não será publicado. Campos obrigatórios são marcados com *